Best Calming Treats for Dog Anxiety in the USA: Top 6 Picks (2025)
Best Calming Treats for Dog Anxiety USA. Help soothe your anxious dog with natural, vet-approved calming treats. See our top six picks for U.S. pet owners and learn how to choose the best one.
Why Use Calming Treats?
Calming treats are easy-to-administer, tasty supplements made from ingredients like L‑theanine, chamomile, hemp, and melatonin. They can help reduce stress during everyday triggers—like car rides, boarding, or vet visits. Best Calming Treats for Dog Anxiety USA
Top 6 Calming Treats for Dog Anxiety (USA, 2025)
1. Zesty Paws Calming Bites
Price: $24.99 (90 treats)
Popular blend with chamomile, melatonin, and L‑theanine. Vet-formulated with over 50,000 5‑star reviews.
2. PetHonesty Calming Hemp Oil Chews
Price: $35.00 (30 chews)
Cannabis‑derived hemp oil and chamomile. Broad-spectrum CBD (0% THC). Great for moderate anxiety.
3. Nordia Calming Treats
Price: $32.99 (60 chews)
Melatonin-based treats—ideal for nighttime anxiety like thunderstorms or firework events.
| Brand | Nordic Naturals |
| Flavor | Unflavored |
| Item Form | Liquid |
| Item Weight | 1.57 Pounds |
| Product Benefits | Heart Health |
4. Vet’s Best Calming Chews
Vet’s Best Comfort Calm Soft Chews promote calm and balanced behavior in nervous, hyper, or discontented dogs. A vet-formulated blend of plant-based ingredients in each once-a-day soft chew supports non-drowsy relaxation and helps reduce separation anxiety.
The OptiLife3™ Formula provides antioxidants and prebiotics to support healthy immune and digestive systems and reduce the effects of normal environmental stress.
Our chews are extra moist, great-tasting, and made for optimal absorption. Made with quality globally sourced ingredients!
Price: $27.50 (45 chews)
About this item
- CALMING RELIEF FOR DOGS – Vet’s Best Comfort Calm, Soft Chews for Dogs (30 count) is a veterinarian-formulated calming aid to support balanced behavior and promote relaxation with a once-a-day supplement.
- FLEXIBLE DOSAGE—Densely packed with active ingredients providing a high level of bioavailability for optimal absorption, our Comfort Calm Soft Chews give you the ease and simplicity of a once-a-day supplement or can be taken as needed.
- INFUSED WITH OCEAN KELP—Our OptiLife3 formula, made with natural ocean kelp, provides antioxidants and prebiotics to reduce the effects of normal environmental stress and support a healthy immune system and digestive health.
- VETERINARIAN-FORMULATED—Each soft chew contains a soothing blend of tryptophan and natural thiamine, valerian root, chamomile, and ginger root for non-drowsy relaxation, balanced behavior, and motion sickness prevention.
- MADE IN THE USA—One package contains 30 soft chew supplements in a delicious once-per-day treat for dogs and puppies (over 12 weeks old) and carries the National Animal Supplement Council (NASC) Quality Seal.
5. NaturVet Quiet Moments Soft Chews
Price: $24.99 (60 chews)
Quiet Moments Dog Calming Soft Chews. Veterinarian formulated for use in dogs over the age of 12 weeks. Our unique blend of thiamine and L‑tryptophan helps reduce stress and tension. Ginger supports sensitive stomachs, which is especially important when traveling, while melatonin helps to promote rest and relaxation. Chamomile and ginger extract. Perfect for mild stress and travel sickness prevention.
- Helps reduce stress and tension.
- Great for storms, fireworks, travel, and grooming.
Veterinarian formulated for use in dogs over the age of 12 weeks. Our unique blend of thiamine and L‑tryptophan helps reduce stress and tension. Ginger supports sensitive stomachs, which is especially important when traveling, while melatonin helps to promote rest and relaxation.
6. Buddy & Lola Calming Bites
Price: $29.99 (60 chews)
Human-grade ingredients, cookie-shaped—pets love them during thunderstorms or separation anxiety.
- FOR A STRESS-FREE PUP— Passiflora incarnata is one of the main ingredients in our natural calming supplement chews, and it helps support your dog’s dopamine levels for a “feel good” effect. Combined with chamomile and B vitamins, these plant-based chews help support dogs staying relaxed during events like fireworks, travel, and vet visits—pretty much any situation that might cause them stress.
- TUMMY-FRIENDLY INGREDIENTS— Because we want your dog to feel its best, all of our ingredients are easy on the stomach, especially if your dog has an allergy to chicken or pork, as these chews are meat-free!
- KEEP YOUR DOG CALM AND COLLECTED— Dogs are often anxious in certain situations, like during a thunderstorm or when visiting the vet. That’s where our all-natural supplement comes in.
- CALMING TREATS WITH NO SEDATIVE EFFECT—Unlike other calmers on the market that contain harsh sedatives, our supplement uses L-Tryptophan, which supports the production of the calming compound serotonin. B vitamins support healthy brain function, targeting excitability and supporting concentration.
- PREMIUM, NATURAL INGREDIENTS—With premium ingredients that help support your dog’s stress responses, our calming treats make it easy for them to stay calm and collected.
How to Choose the Right Treat
- Check the active ingredient (CBD vs melatonin vs herbal).
- Adjust dosage by weight—always follow label directions.
- Look for products free from artificial additives or grains.
- Start a few days before an expected anxiety event.
Real Results & Vet Advice
In clinical trials, 80% of dogs showed decreased anxiety signs with melatonin-based treats, while CBD-based chews are gaining popularity—especially for older dogs.
FAQ
- Are calming treats safe for puppies?
- Check weight-based dosage; avoid CBD for those under 10 weeks old.
- How long until they work?
- Typically 30–60 minutes before a stressor; melatonin can last 4–6 hours.
- Any side effects?
- Sleepiness or mild digestive upset is possible—always test first.
More Resources & Internal Links
Want to complement treats with other tools? Try our calming vests guide or download the Calm Dog Checklist.